Cell Painting for cytotoxicity and mode-of-action analysis in primary human hepatocytes

Image-based profiling (Cell Painting) combined with cytotoxicity assays to study hepatocyte responses.

Read on bioRxiv

PKSmart: an open-source computational model to predict intravenous pharmacokinetics of small molecules

Machine-learning models (open source + web app) predicting human PK parameters from structure and predicted animal PK.

Read in Journal of Cheminformatics

OASIS Consortium: Integrating Multi-Omics Technologies to Advance Safety Assessment

Forum piece from the OASIS consortium outlining multi-omics integration for safety assessment.

Read in Toxicological Sciences

Improved Detection of Drug-Induced Liver Injury by Integrating Predicted & Experimental Data

Combines predicted in vivo and in vitro data to boost DILI detection performance.

Read in Chem. Research in Toxicology